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Donatella  de Pascale

Donatella de Pascale

Education

Ph.D in Design and Application of New Molecules of Biotechnological Interest. Second University of Naples (SUN), 2000

Current position

Staff Researcher (Ricercatore III fascia), Group Leader, Institute of Protein Biochemistry National Research Council (IBP-CNR) Naples, Italy

Publications (since 2012)

  1. Presta, L., Inzucchi, I., Bosi, E., Fondi, M., Perrin, E., Miceli, E., Tutino, M. L., Lo Giudice, A., de Pascale, D. and Fani, R. (2016). Draft Genome Sequence of Flavobacterium sp. Strain TAB 87, Able To Inhibit the Growth of Cystic Fibrosis Bacterial Pathogens Belonging to the Burkholderia cepacia Complex. Genome Announc 4(3).

  2. Gnavi, G., Palma Esposito, F., Festa, C., Poli, A., Tedesco, P., Fani, R., Monti, M. C., de Pascale, D., D'Auria, M. V. and Varese, G. C. (2016). The antimicrobial potential of algicolous marine fungi for counteracting multidrug-resistant bacteria: phylogenetic diversity and chemical profiling. Res Microbiol 167(6): 492-500.

  3. Tedesco, P., Maida, I., Palma Esposito, F., Tortorella, E., Subko, K., Ezeofor, C. C., Zhang, Y., Tabudravu, J., Jaspars, M., Fani, R. and de Pascale, D. (2016). Antimicrobial Activity of Monoramnholipids Produced by Bacterial Strains Isolated from the Ross Sea (Antarctica). Mar Drugs 14(5).

  4. Jaspars, M., de Pascale, D., Andersen, H. J., Reyes, F., Crawford, A. D. and Ianora, A. (2016). The marine biodiscovery pipeline and ocean medicines of tomorrow. Journal of Marine Biological Association of the United Kindom, 96(1), 151-158.

  5. De Santi, C., Leiros, H. K., Di Scala, A., de Pascale, D., Altermark, B. and Willassen, N. P. (2016). Biochemical characterization and structural analysis of a new cold-active and salt-tolerant esterase from the marine bacterium Thalassospira sp. Extremophiles 20(3): 323-336.

  6. De Santi, C., Altermark, B., Pierechod, M. M., Ambrosino, L., de Pascale, D. and Willassen, N. P. (2016). Characterization of a cold-active and salt tolerant esterase identified by functional screening of Arctic metagenomic libraries. BMC Biochem 17: 1.

  7. De Santi, C., Altermark, B., de Pascale, D. and Willassen, N. P. (2016). Bioprospecting around Arctic islands: Marine bacteria as rich source of biocatalysts. J Basic Microbiol 56(3): 238-253.

  8. Tedesco, P., Visone, M., Parrilli, E., Tutino, M. L., Perrin, E., Maida, I., Fani, R., Ballestriero, F., Santos, R., Pinilla, C., Di Schiavi, E., Tegos, G. and de Pascale, D. (2015). Investigating the Role of the Host Multidrug Resistance Associated Protein Transporter Family in Burkholderia cepacia Complex Pathogenicity Using a Caenorhabditis elegans Infection Model. PLoS One 10(11): e0142883.

  9. De Santi, C., Ambrosino, L., Tedesco, P., Zhai, L., Zhou, C., Xue, Y., Ma, Y. and de Pascale, D. (2015). Identification and characterization of a novel salt-tolerant esterase from a Tibetan glacier metagenomic library. Biotechnol Prog 31(4): 890-899.

  10. Maida, I., Bosi, E., Fondi, M., Perrin, E., Orlandini, V., Papaleo, M. C., Mengoni, A., de Pascale, D., Tutino, M. L., Michaud, L., Lo Giudice, A. and Fani, R. (2015). Antimicrobial activity of Pseudoalteromonas strains isolated from the Ross Sea (Antarctica) vs Cystic Fibrosis opportunistic pathogens. Hydrobiologia.

  11. Barone, R., De Santi, C., Palma Esposito, F., Tedesco, P., Galati, F., Visone, M., Di Scala, A. and de Pascale, D. (2015). Marine metagenomics, a valuable tool for enzymes and bioactive compounds discovery. Front. Mar. Sci.

  12. Tedesco, P., Visone, M., Parrilli, E., Tutino, M. L., Perrin, E., Maida, I., Fani, R., Tegos, G. and de Pascale, D. (2014). Analysis of virulence factors of Burkholderia cepacia complex strains in the Caenorhabtidis elegans host model. J Biotechnol Biomater 3:5, 219-220.

  13. de Pascale, D. (2014). Exploiting the cold environments: Psychrophilic bacteria as a promising source of novel bioactive compounds. J Biotechnol Biomater 3:108-109.

  14. Buonocore, F., Randelli, E., Trisolino, P., Facchiano, A., de Pascale, D. and Scapigliati, G. (2014). Molecular characterization, gene structure and antibacterial activity of a g-type lysozyme from the European sea bass (Dicentrarchus labrax L.). Mol Immunol 62(1): 10-18.

  15. De Santi, C., Tedesco, P., Ambrosino, L., Altermark, B., Willassen, N. P. and de Pascale, D. (2014). A new alkaliphilic cold-active esterase from the psychrophilic marine bacterium Rhodococcus sp.: functional and structural studies and biotechnological potential. Appl Biochem Biotechnol 172(6): 3054-3068.

  16. Fondi, M., Orlandini, V., Perrin, E., Maida, I., Bosi, E., Papaleo, M. C., Michaud, L., Lo Giudice, A., de Pascale, D., Tutino, M. L., Lio, P. and Fani, R. (2014). Draft genomes of three Antarctic Psychrobacter strains producing antimicrobial compounds against Burkholderia cepacia complex, opportunistic human pathogens. Mar Genomics 13: 37-38.

  17. Maida, I., Fondi, M., Papaleo, M. C., Perrin, E., Orlandini, V., Emiliani, G., de Pascale, D., Parrilli, E., Tutino, M. L., Michaud, L., Lo Giudice, A., Romoli, R., Bartolucci, G. and Fani, R. (2014). Phenotypic and genomic characterization of the Antarctic bacterium Gillisia sp. CAL575, a producer of antimicrobial compounds. Extremophiles 18(1): 35-49.

  18. Orlandini, V., Maida, I., Fondi, M., Perrin, E., Papaleo, M. C., Bosi, E., de Pascale, D., Tutino, M. L., Michaud, L., Lo Giudice, A. and Fani, R. (2014). Genomic analysis of three sponge-associated Arthrobacter Antarctic strains, inhibiting the growth of Burkholderia cepacia complex bacteria by synthesizing volatile organic compounds. Microbiol Res 169(7-8): 593-601.

  19. Yang, G., De Santi, C., de Pascale, D., Pucciarelli, S., Pucciarelli, S. and Miceli, C. (2013). Characterization of the first eukaryotic cold-adapted patatin-like phospholipase from the psychrophilic Euplotes focardii: Identification of putative determinants of thermal-adaptation by comparison with the homologous protein from the mesophilic Euplotes crassus. Biochimie 95(9): 1795-1806.

  20. Romoli, R., Papaleo, M. C., de Pascale, D., Tutino, M. L., Michaud, L., Lo Giudice, A., Fani, R. and Bartolucci, G. (2013). GC-MS Volatolomic Approach to Study the Antimicrobial Activity of the Antarctic Bacterium Pseudoalteromonas sp. TB41. Metabolomics. (2013) vol. 10, pp. 42-51.

  21. Fu, J., Leiros, H. K., de Pascale, D., Johnson, K. A., Blencke, H. M. and Landfald, B. (2013). Functional and structural studies of a novel cold-adapted esterase from an Arctic intertidal metagenomic library. Appl Microbiol Biotechnol 97(9): 3965-3978.

  22. de Pascale, D., De Santi, C., Fu, J. and Landfald, B. (2012). The microbial diversity of Polar environments is a fertile ground for bioprospecting. Mar Genomics 8: 15-22.

  23. de Pascale, D., De Santi, C., Fu, J. and Landfald, B. (2012). The microbial diversity of Polar environments is a fertile ground for bioprospecting. Mar Genomics 8: 15-22.

  24. Fondi, M., Orlandini, V., Maida, I., Perrin, E., Papaleo, M. C., Emiliani, G., de Pascale, D., Parrilli, E., Tutino, M. L., Michaud, L., Lo Giudice, A. and Fani, R. (2012). Draft genome sequence of the volatile organic compound-producing Antarctic bacterium Arthrobacter sp. strain TB23, able to inhibit cystic fibrosis pathogens belonging to the Burkholderia cepacia complex. J Bacteriol 194(22): 6334-6335.

  25. Buonocore, F., Randelli, E., Casani, D., Picchietti, S., Belardinelli, M. C., de Pascale, D., De Santi, C. and Scapigliati, G. (2012). A piscidin-like antimicrobial peptide from the icefish Chionodraco hamatus (Perciformes: Channichthyidae): molecular characterization, localization and bactericidal activity. Fish Shellfish Immunol 33(5): 1183-1191.

  26. De Santi, C., Durante, L., Vecchio, P. D., Tutino, M. L., Parrilli, E. and de Pascale, D. (2012). Thermal stabilization of psychrophilic enzymes: a case study of the cold-active hormone-sensitive lipase from Psychrobacter sp. TA144. Biotechnol Prog 28(4): 946-952.

  27. Ascione, G., de Pascale, D., De Santi, C., Pedone, C., Dathan, N. A. and Monti, S. M. (2012). Native expression and purification of hormone-sensitive lipase from Psychrobacter sp. TA144 enhances protein stability and activity. Biochem Biophys Res Commun 420(3): 542-546.

  28. Mandrich, L., De Santi, C., de Pascale, D. and Manco, G. (2012). Effect of low organic solvents concentration on the stability and catalytic activity of HSL-like carboxylesterases: Analysis from psychrophiles to (hyper)thermophiles. Journal Molecular Catalysis: B enzymatic, 82: 46– 52.

Protocols by Donatella de Pascale
  1. Evaluation of Burkholderia cepacia Complex Bacteria Pathogenicity Using Caenorhabditis elegans